Abstract #3702

Platform for Hyperpolarized 13C MRI of Breast Cancer

Benjamin Joseph Geraghty^1,2, Justin YC Lau^1,2, Logi Vidarsson³, William Dominguez-Viqueira⁴, Albert P Chen⁵, and Charles Cunningham^1,2

¹Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³LT Imaging Inc., Toronto, ON, Canada, ⁴Moffitt Cancer Center, Tampa, FL, United States, ⁵GE Healthcare, Toronto, ON, Canada

A platform consisting of a dual-echo 3D echo-planar pulse sequence and a custom coil system was implemented and tested for metabolic imaging of breast cancer. A two-channel unilateral breast ¹³C receive array was designed for integration with the Sentinelle Vanguard Breast MRI system. A single-loop coil was designed for RF excitation. The highly ergonomic design enables the operator to swap between proton and ¹³C breast coils without moving the patient, providing intrinsically registered anatomical and metabolic data. Phantom data and hyperpolarized ¹³C pre-clinical rat images were obtained and are presented. The proposed coil system represents important progress towards a viable breast cancer patient study.

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