Abstract #3706

Hyperpolarized Magnetic Resonance Imaging of Silicon Microparticles Functionalized with Mucin Antibody: Towards Molecular Targeting of Colorectal Cancer

Nicholas Whiting¹, Jingzhe Hu^1,2, Julie X Liu³, Klaramari Gellci^1,4, Pamela Constantinou³, Jennifer Davis⁵, Niki Zacharias Millward¹, David G Menter⁶, Daniel Carson³, and Pratip Bhattacharya¹

¹Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²Department of Bioengineering, Rice University, Houston, TX, United States, ³Department of Biosciences, Rice University, Houston, TX, United States, ⁴Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, ⁵Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁶Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Hyperpolarized silicon nano- and microparticles hold great promise as targeted molecular imaging agents due to their overall biocompatibility and long-lasting enhanced MRI signals. We performed dynamic nuclear polarization on silicon microparticles that were functionalized with an antibody that targets Mucin overexpression in colorectal cancer. Conjugation of the antibody to the particle surface did not affect the ²⁹Si hyperpolarization characteristics, and in vivo imaging was attained 20 minutes after particle injection into a colorectal cancer mouse model. The goal is to develop these targeted particles as a platform technology that will allow non-invasive screening of colorectal cancer using ²⁹Si MRI.

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