Hyperpolarization (HP) of the 13C magnetic resonance signal of [1-13C]-lactate has been obtained using the ParaHydrogen Induced Polarization by means of Side Arm Hydrogenation (PHIP-SAH). Different ester derivatives of lactate have been tested in order to optimize the hydrogenation kinetics and the polarization level on the product. The metabolic transformation of hyperpolarized [1-13C]-lactate into pyruvate has been observed in vitro. The bio-compatibility of the aqueous solution and the good polarization level (7.9±0.4%) make the hyperpolarized metabolite thus obtained a good candidate for metabolic imaging studies.
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