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Abstract #3707

13C-MR Hyperpolarization of Lactate using ParaHydrogen and metabolic transformation in vitro.

Eleonora Cavallari1, Carla Carrera1, Silvio Aime1, and Francesca Reineri1

1Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy

Hyperpolarization (HP) of the 13C magnetic resonance signal of [1-13C]-lactate has been obtained using the ParaHydrogen Induced Polarization by means of Side Arm Hydrogenation (PHIP-SAH). Different ester derivatives of lactate have been tested in order to optimize the hydrogenation kinetics and the polarization level on the product. The metabolic transformation of hyperpolarized [1-13C]-lactate into pyruvate has been observed in vitro. The bio-compatibility of the aqueous solution and the good polarization level (7.9±0.4%) make the hyperpolarized metabolite thus obtained a good candidate for metabolic imaging studies.

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