Hyperpolarized pyruvate can be used to noninvasively probe metabolism in vivo. However, quantitative measurement of metabolic processes is frequently complicated by tissue perfusion. Metabolic inert compounds such as hyperpolarized urea have been used to measure tissue perfusion. This work shows a strong correlation between hyperpolarized urea signal and the sum of hyperpolarized pyruvate and lactate signal, suggesting that the combination of pyruvate and lactate signals can be used to estimate tissue perfusion.
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