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Abstract #3709

Measuring cerebral glucose metabolism in vivo using hyperpolarized 13C labelled glucose

Mor Mishkovsky1,2, Brian Anderson3, Magnus Karlsson4, Mathilde H Lerche4, A Dean Sherry3, Rolf Gruetter1,5,6, Zoltan Kovacs3, and Arnaud Comment2,7

1Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland, 2Institute of Physics of Biological Systems, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland, 3Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Albeda Research, ApS, Copenhagen, Denmark, 5Department of Radiology, Universite de Lausanne, Lausanne, Switzerland, 6Department of Radiology, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland, 7General Electric Healthcare, Buckinghamshire HP8 4SP, United Kingdom

Real-time glucose metabolism was observed in healthy mice brain following infusion of hyperpolarized [U-2H, U-13C]glucose and [U-2H, 3,4-13C]glucose. The evolution of lactate formation was readily observed. In addition, two glycolysis metabolites, namely 3-phosphoglycerate and pyruvate, were identified. Abnormalities in cerebral glucose metabolism is associated with large number of diseases so implementation of this method may prove useful in imaging brain metabolism in various animal models.

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Abstract