Abstract #3709

Measuring cerebral glucose metabolism in vivo using hyperpolarized 13C labelled glucose

Mor Mishkovsky^1,2, Brian Anderson³, Magnus Karlsson⁴, Mathilde H Lerche⁴, A Dean Sherry³, Rolf Gruetter^1,5,6, Zoltan Kovacs³, and Arnaud Comment^2,7

¹Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland, ²Institute of Physics of Biological Systems, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland, ³Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴Albeda Research, ApS, Copenhagen, Denmark, ⁵Department of Radiology, Universite de Lausanne, Lausanne, Switzerland, ⁶Department of Radiology, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland, ⁷General Electric Healthcare, Buckinghamshire HP8 4SP, United Kingdom

Real-time glucose metabolism was observed in healthy mice brain following infusion of hyperpolarized [U-²H, U-¹³C]glucose and [U-²H, 3,4-¹³C]glucose. The evolution of lactate formation was readily observed. In addition, two glycolysis metabolites, namely 3-phosphoglycerate and pyruvate, were identified. Abnormalities in cerebral glucose metabolism is associated with large number of diseases so implementation of this method may prove useful in imaging brain metabolism in various animal models.

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