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Abstract #3710

Production of Highly Polarized Acetate by Rapid Decarboxylation of Pyruvate – Application to Hyperpolarized Cardiac Spectroscopy

Jonas Steinhauser1, Grzegorz Kwiatkowski 1, Patrick Wespi1, and Sebastian Kozerke1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

In this work rapid decarboxylation of [1,2-13C]pyruvate using hydrogen peroxide was employed to obtain hyperpolarized [1-13C]acetate. 13C polarization was transferred completely and reproducibly. The application of the concept is demonstrated for detecting [1-13C]acetate and [1-13C]acetylcarnitine in the in-vivo heart.

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