Abstract #3710

Production of Highly Polarized Acetate by Rapid Decarboxylation of Pyruvate – Application to Hyperpolarized Cardiac Spectroscopy

Jonas Steinhauser¹, Grzegorz Kwiatkowski ¹, Patrick Wespi¹, and Sebastian Kozerke¹

¹Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

In this work rapid decarboxylation of [1,2-13C]pyruvate using hydrogen peroxide was employed to obtain hyperpolarized [1-13C]acetate. 13C polarization was transferred completely and reproducibly. The application of the concept is demonstrated for detecting [1-13C]acetate and [1-13C]acetylcarnitine in the in-vivo heart.

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