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Abstract #3729

Ex vivo whole-blood $$$T_2$$$ versus $$$HbO_2$$$ calibration for $$$T_2$$$-prepared balanced steady-state free precession (bSSFP) at 1.5T

Ana E Rodríguez-Soto1, Michael C Langham1, Osheiza Abdulmalik2, and Felix W Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States

The transverse relaxation rate (1/T2) of blood water protons is governed by deoxyhemoglobin concentration, therefore providing a means to determine oxygen saturation (HbO2) in vivo. However, besides CPMG inter-pulse interval of the T2 preparation and field strength, whole-blood T2 depends on sequence-specific parameters. Balanced SSFP allows for rapid image acquisition and higher in-plane resolution and thus provides an ideal readout for T2-based oximetry. Here, we quantified T2 of human blood at 1.5T for the entire range of HbO2 saturation levels using T2-prepared bSSFP sequence. The data show the expected linearity of 1/T2 with (1-HbO2)2 with the y-intercept depending on hematocrit.

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