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Abstract #3730

Inversion-recovery Ultrashort Echo Time Imaging with Bi-component T2* Analysis of White Matter Signals in Native and Deuterated Ovine Brain Specimens

Shu-Juan Fan1, Yajun Ma1, Eric Y Chang1,2, and Jiang Du1

1Dept. of Radiology, University of California, San Diego, San Diego, CA, United States, 2Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Myelin protons have ultrashort-lived MR signals and are not accessible by clinical MRI. Such signals were probed herein using ultrashort echo time imaging (UTE) and inversion-recovery UTE (IR-UTE) with bi-component analysis in native and deuterated ovine brain specimens. UTE detected a fraction of ultrashort T2 components (STC) of < 4% in native specimens, and up to ~54% in deuterated specimens. Choice of inversion time in IR-UTE significantly affected such bi-component signal decay behavior in native samples in heavily deuterated samples. These results support the application of UTE and IR-UTE in quantitative myelin imaging.

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