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Abstract #3731

Novel nanogel-based MRI Contrast Agents

Brendan Garrett1, Simon Duckett2, David K. Smith1, and Victor Chechik1

1Department of Chemistry, University of York, YORK, United Kingdom, 2Centre for Hyperpolarisation in Magnetic Resonance, University of York, YORK, United Kingdom

We present here the preparation and properties of new Gd3+-containing nanogel-based contrast agents. These gel nanoparticles are prepared by simple ionotropic gelation from sodium alginate and Gd3+. The nanogels are 100-200 nm in diameter and have a high R1 relaxivity of ≈ 30 mM-1 s-1 at 1 T, however, they have poor stability in high ionic strength media. Adding further covalent crosslinks with a suitable agent such as epichlorohydrin dramatically increased the relaxivity of the nanogels to ≈ 60 mM-1 s-1 at 1 T and provides a viable strategy to increases their stability against transmetallation.

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