We present here the preparation and properties of new Gd3+-containing nanogel-based contrast agents. These gel nanoparticles are prepared by simple ionotropic gelation from sodium alginate and Gd3+. The nanogels are 100-200 nm in diameter and have a high R1 relaxivity of ≈ 30 mM-1 s-1 at 1 T, however, they have poor stability in high ionic strength media. Adding further covalent crosslinks with a suitable agent such as epichlorohydrin dramatically increased the relaxivity of the nanogels to ≈ 60 mM-1 s-1 at 1 T and provides a viable strategy to increases their stability against transmetallation.
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