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Abstract #3732

Quantitative validation of Spin Echo and Magnetic Resonance Fingerprinting derived Proton Density using the qMRI Phantom

Gregory Lemberskiy1,2, Els Fieremans1, Dmitry S Novikov1, and Martijn Cloos1

1Radiology, NYU School of Medicine, New York, NY, United States, 2Sackler Institute of Graduate Biomedical Sciences, NYU School of Medicine, New York, NY, United States

Proton density (PD) measurements derived from single Spin Echo and PnP-MRF, which is a fingerprinting protocol that enables simultaneous estimation of the excitation field (B1+), were validated using the ISMRM/NIST MRI system phantom that contains known D2O/H2O solutions at 14 different concentrations. We also expanded the PnP-MRF protocol by exploiting the symmetry between B1+ and the receive field, B1-, produced by a quadrature body coil at 3 Tesla in order to remove all B1 contribution from our PD. Ultimately, all methods showed remarkable correlation with the known water fraction from NIST samples (Pearson’s rho>0.99).

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