Proton density (PD) measurements derived from single Spin Echo and PnP-MRF, which is a fingerprinting protocol that enables simultaneous estimation of the excitation field (B1+), were validated using the ISMRM/NIST MRI system phantom that contains known D2O/H2O solutions at 14 different concentrations. We also expanded the PnP-MRF protocol by exploiting the symmetry between B1+ and the receive field, B1-, produced by a quadrature body coil at 3 Tesla in order to remove all B1 contribution from our PD. Ultimately, all methods showed remarkable correlation with the known water fraction from NIST samples (Pearson’s rho>0.99).
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