Abstract #3736

In Vivo Tracking of Hyaluronic Acid Hydrogel Degradation Using Temporal Evolution of Chemical Exchange Saturation Transfer Signal in a Mouse Subcutaneous Injection Model

Mohammed Salman Shazeeb¹, Rubina Corazzini², Dinesh Bangari³, Robert Fogle¹, Jennifer Johnson³, Paul J. Konowicz², Xiaoyou Ying¹, and Pradeep K. Dhal²

¹Bioimaging, Translational In Vivo Models, Sanofi, Framingham, MA, United States, ²Biomaterials, Sanofi, Framingham, MA, ³Pathology, Translational In Vivo Models, Sanofi, Framingham, MA

Hyaluronic acid (HA) hydrogels have a wide range of applications in biomedicine from regenerative medicine to drug delivery applications. In vivo quantitative assessment of these hydrogels using magnetic resonance imaging (MRI) provides a powerful technique to assess the biodegradability of HA hydrogels. This study investigated the potential of chemical exchange saturation transfer (CEST) MRI in tracking HA hydrogels with varying degradation profiles in vivo in a mouse subcutaneous injection model over 77 days. Since CEST-MRI provides a unique chemical signature to visualize HA hydrogels, this technique can be used as a guide in hydrogel optimization process for drug delivery applications.

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