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Abstract #3737

Magnetization Transfer MRI Noninvasively Detects Renal Fibrosis Swine Atherosclerotic Renal Artery Stenosis at 3.0 T

Kai Jiang1, Christopher M. Ferguson1, John R. Woollard1, Roger C. Grimm2, James D. Krier1, Xiangyang Zhu1, and Lilach O. Lerman1

1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States, 2Department of Radiology, Mayo Clinic, Rochester, MN, United States

In this study, we tested the capability of magnetization transfer (MT) imaging for measuring renal fibrosis in a swine model of atherosclerotic renal artery stenosis (ARAS) at 3.0 T. A collagen phantom study was performed to select appropriate offset frequencies of MT pulses for collagen detection. In an in vivo study, the MT ratio (MTR) and percent change in MTR between two offset frequencies were quantified, and both showed a good correlation with renal fibrosis measured ex vivo by Picro-Sirius red staining, supporting the use of MT to assess renal fibrosis in swine ARAS.

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