Abstract #3740

In Vivo Detection of Reactive Oxygen Species Using MRI with Endogenous Contrast

Rong-Wen Tain^1,2, Alessandro Scotti^1,2,3, Weiguo Li^4,5, Xiaohong Joe Zhou^1,2,3,6, Riya Thomas⁷, Leon Tai⁷, and Kejia Cai^1,2,3

¹Radiology, University of Illinois at Chicago, Chicago, IL, United States, ²Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, ³Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ⁴Research Resource Center, University of Illinois at Chicago, Chicago, IL, United States, ⁵Radiology, Northwestern University, Chicago, IL, United States, ⁶Neurosurgery, University of Illinois at Chicago, Chicago, IL, United States, ⁷Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States

Reactive oxygen species (ROS) contribute to pathogenesis of many human diseases including Parkinson’s and Alzheimer's diseases, cancer, and diabetes. There is a crucial need for using fully noninvasive imaging to further evaluate the role of ROS in pathogenesis and the potential treatment strategies. Our previous phantom studies demonstrated that ROS containing unpaired electrons can be detected with endogenous CEST and T₁ weighted contrasts. However, in vivo detection of ROS using MRI has not yet been demonstrated. This study therefore aimed to demonstrate the feasibility of in vivo ROS detection using endogenous MRI.

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