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Abstract #3741

Imaging of neuronal compartment using gluCEST method

Jérémy Pépin1, Pierrick Jego1, Julien Valette1, Gilles Bonvento1, and Julien Flament1,2

1Molecular Imaging Research Center (MIRCen), Commissariat à l’Energie Atomique (CEA), Fontenay-aux-Roses, France, 2UMS27, INSERM, Fontenay-aux-Roses, France

GluCEST imaging has been proposed to image brain glutamate distribution with a better resolution than spectroscopic methods and has many potential applications for the study of neurodegenerative diseases. In this study, we pushed further the limits of gluCEST imaging by combining high magnetic field and high performance cryoprobe to acquire gluCEST images with the best resolution so far. Thanks to the organization of hippocampal cell layers and the high resolution, we acquired gluCEST data in regions mostly reflecting the neuronal compartment.

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