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Abstract #3750

A longitudinal study of brain tumors in the course of radiotherapy using protein CEST MRI at 7T

Jan-Eric Meissner1, Andreas Korzowski1, Sebastian Adeberg2, Steffen Goerke1, Nicolas Behl1, Heinz-Peter Schlemmer3, J├╝rgen Debus2, Mark E. Ladd1, Peter Bachert1, and Daniel Paech3

1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 2Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany, 3Radiology, German Cancer Research Center, Heidelberg, Germany

Chemical Exchange Saturation Transfer (CEST) offers unique contrasts sensitive to micro environmental information such as protein concentration and pH. Thus CEST could be a promising biomarker to investigate radiotherapy-induced changes in tissue. In this study we examine brain tumor patients in the course of definitive radiotherapy on a 7 T whole-body scanner using the relaxation compensated contrast AREX. We compare the results of CEST imaging to Single Voxel Spectroscopy and high-resolution T2-weighted imaging.

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