Abstract #3750

A longitudinal study of brain tumors in the course of radiotherapy using protein CEST MRI at 7T

Jan-Eric Meissner¹, Andreas Korzowski¹, Sebastian Adeberg², Steffen Goerke¹, Nicolas Behl¹, Heinz-Peter Schlemmer³, Jürgen Debus², Mark E. Ladd¹, Peter Bachert¹, and Daniel Paech³

¹Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, ²Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany, ³Radiology, German Cancer Research Center, Heidelberg, Germany

Chemical Exchange Saturation Transfer (CEST) offers unique contrasts sensitive to micro environmental information such as protein concentration and pH. Thus CEST could be a promising biomarker to investigate radiotherapy-induced changes in tissue. In this study we examine brain tumor patients in the course of definitive radiotherapy on a 7 T whole-body scanner using the relaxation compensated contrast AREX. We compare the results of CEST imaging to Single Voxel Spectroscopy and high-resolution T₂-weighted imaging.

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