Abstract #3751

Voxel-wise comparison of amide proton transfer (APT) weighted image and fluorodeoxyglucose (FDG)-PET in brain tumors with a PET/MR system

Koji Sagiyama¹, Yuji Watanabe², Ryotaro Kamei¹, Sungtak Hong³, Jochen Keupp⁴, and Hiroshi Honda¹

¹Department of Clinical Radiology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, ²Department of Molecular Imaging and Diagnosis, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, ³Healthcare, Philips Electronics Japan, ⁴Philips Research

Amide proton transfer (APT) imaging has been reported to be useful for assessing malignancy or evaluating treatment efficacy. In this study, we evaluated the validity of APT signals in brain tumors by direct voxel-wise comparison with standardized uptake values (SUVs) from fluorodeoxyglucose positron emission tomography (FDG-PET) on a PET-magnetic resonance (PET/MR) system. APT imaging showed discrepancies with FDG-PET due to structural inhomogeneity, and the correlation between APT signals and SUVs was poor. The correlation was significantly improved after correcting for the apparent diffusion coefficient (ADC). APT/ADC could be a reliable metabolic marker with better correlation with SUVs.

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