Abstract #3752

Repeatability study of APT CEST quantification techniques for identification of ischaemic penumbra in stroke

Yunus Msayib^1,2, George W. J. Harston³, Yee K. Tee⁴, Fintan Sheerin³, Nicholas P. Blockley⁵, Thomas W. Okell⁵, Peter Jezzard⁵, Stephen Payne¹, James Kennedy³, and Michael A. Chappell¹

¹Engineering Science, University of Oxford, Oxford, United Kingdom, ²Centre for Doctoral Training in Healthcare Innovation, University of Oxford, Oxford, United Kingdom, ³Radcliffe Department of Medicine, University of Oxford, ⁴Department of Mechatronics and Biomedical Engineering, Universiti Tunku Abdul Rahman, ⁵Nuffield Department of Clinical Neurosciences, University of Oxford

The aim of this study was to identify the analysis technique with the optimum repeatability for quantifying APT CEST imaging for use in the clinical setting. The repeatability of eight quantification techniques was assessed across imaging time points in healthy subjects, and between the contralateral hemispheres of stroke patients. Model-based techniques exhibited better repeatability compared to simpler model-free methods, and are thus better-suited for use in clinical imaging at 3T.

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