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Abstract #3752

Repeatability study of APT CEST quantification techniques for identification of ischaemic penumbra in stroke

Yunus Msayib1,2, George W. J. Harston3, Yee K. Tee4, Fintan Sheerin3, Nicholas P. Blockley5, Thomas W. Okell5, Peter Jezzard5, Stephen Payne1, James Kennedy3, and Michael A. Chappell1

1Engineering Science, University of Oxford, Oxford, United Kingdom, 2Centre for Doctoral Training in Healthcare Innovation, University of Oxford, Oxford, United Kingdom, 3Radcliffe Department of Medicine, University of Oxford, 4Department of Mechatronics and Biomedical Engineering, Universiti Tunku Abdul Rahman, 5Nuffield Department of Clinical Neurosciences, University of Oxford

The aim of this study was to identify the analysis technique with the optimum repeatability for quantifying APT CEST imaging for use in the clinical setting. The repeatability of eight quantification techniques was assessed across imaging time points in healthy subjects, and between the contralateral hemispheres of stroke patients. Model-based techniques exhibited better repeatability compared to simpler model-free methods, and are thus better-suited for use in clinical imaging at 3T.

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