It has been shown that the changes in chemical exchange saturation transfer (CEST), and specifically amide proton transfer (APT) and nuclear Overhauser effect (NOE), reflect abnormal tissues in tumor, stroke and other diseases. However, quantitative and specific imaging of these effects is challenging due to the influences from asymmetric magnetization transfer and direct water saturation. These obstacles can be avoided with chemical exchange rotation transfer (CERT), which is a pulsed version of CEST with the constraint of constant average power and varying rotation angle. In this study, we present initial CERT results in human brain at 3 T, with the goal of quantifying APT and NOE.
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