Abstract #3755

Optimization of Amide Proton Transfer (APT) Imaging Experimental Parameters for Brain Tumors: Does RF Saturation Length Always Increase APT Contrast?

Hye-Young Heo^1,2, Yi Zhang¹, Shanshan Jiang¹, and Jinyuan Zhou^1,3

¹Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Current APT imaging studies have used a moderate repetition time or relaxation delay to reduce the scan time. However, when a relatively short relaxation delay compared with T₁ is applied, the steady-state water longitudinal magnetization is reduced, resulting in a decrease in APT effect. Therefore, experimental parameters must be optimized on a combination of the RF saturation power, saturation length, and relaxation delay. Here, we quantitatively investigated the dependence of APT and NOE signals on the experimental parameters using Bloch simulations and rat brain tumor models at 4.7 T.

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