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Abstract #3756

Development of Glutamate-Sensitive CEST at Clinical Field Strength for In Vivo Application

Kristin P. O'Grady1,2, Samantha By2,3, Bailey A. Box1,2, and Seth A. Smith1,2,3

1Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Cognitive impairment (CI) is a significant symptom of multiple sclerosis (MS), is the strongest predictor of unemployment in MS patients, and is critical to the decline of quality of life. There is an unmet need for imaging techniques that probe the pathological substrate of CI at a clinically relevant field strength. To address this need, we have investigated the translation of glutamate-sensitive chemical exchange saturation transfer (GluCEST) MRI to 3T, as glutamate abnormalities have been linked to CI in MS. Our results demonstrate the clinical feasibility of GluCEST imaging for application to studying cortical gray matter glutamate signals in vivo.

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