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Abstract #3758

Interleaved B0-mapping during dynamic Creatine-CEST for correction of temporarily fluctuating B0 inhomogeneities during plantar flexion exercise at 7T

Esau Poblador Rodriguez1, Philipp Moser1, Barbara Dymerska1, Siegfried Trattnig1,2, and Wolfgang Bogner1

1High Field MR Centre. Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Once the time resolution and specificity of Cr-CEST become comparable with 31P-MRS, it may replace it for the diagnosis of muscular disorders and treatment assessment due to its superior spatial resolution and sensitivity. The need of a complete Z-spectrum acquisition for B0 inhomogeneity correction limits the achievable time resolution and is unable to track temporal ∆B0 due to subject movement or B0 field drifts that occur during a CEST experiment. Temporal B0 field tracking allows independent B0 inhomogeneity correction for each z-spectral point, which may substantially improve the reliability of spectral CEST asymmetry analysis.

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