Once the time resolution and specificity of Cr-CEST become comparable with 31P-MRS, it may replace it for the diagnosis of muscular disorders and treatment assessment due to its superior spatial resolution and sensitivity. The need of a complete Z-spectrum acquisition for B0 inhomogeneity correction limits the achievable time resolution and is unable to track temporal ∆B0 due to subject movement or B0 field drifts that occur during a CEST experiment. Temporal B0 field tracking allows independent B0 inhomogeneity correction for each z-spectral point, which may substantially improve the reliability of spectral CEST asymmetry analysis.
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