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Abstract #3766

Accelerating CEST Imaging with Experimental Undersampling and Compressed Sensing

Huajun She1, Bian Li1, Joshua S. Greer1,2, Jochen Keupp3, Ivan E. Dimitrov1,4, Ananth Madhuranthakam1,5, Robert Lenkinski1,5, and Elena Vinogradov1,5

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Bioengineering, UT Dallas, Dallas, TX, United States, 3Philips Research, Hamburg, Germany, 4Philips Healthcare, Gainesville, FL, United States, 5Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Chemical exchange saturation transfer (CEST) is a new contrast mechanism in MRI. However, a successful application of CEST is hampered by its slow acquisition and fast acquisition is desired. Compressed sensing (CS) is powerful for perfect reconstruction of highly undersampled data. Existing works mostly focus on the retrospectively downsampled studies, but few implementation and analysis of truly undersampled scheme with CEST has been reported. This work experimentally implements the random Cartesian undersampled scheme and the golden angle radial sampling sequence for CEST. The results demonstrate influence of experimental conditions that are not accounted for in the retrospectively undersampled studies.

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