Abstract #3770

Separating out Fast and Slow Chemical Exchange Using Off-resonance Variable Delay Multiple Pulse (VDMP)

Lin Chen^1,2,3, Xiang Xu^2,3, Haifeng Zeng^2,3, Kannie W.Y. Chan^2,3,4, Nirbhay Yadav^2,3, Shuhui Cai¹, Kathryn J. Schunke⁵, Nauder Faraday⁵, Peter C. M. van Zijl^2,3, and Jiadi Xu^2,3

¹Department of Electronic Science, Xiamen University, Xiamen, People's Republic of China, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ⁴Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, People's Republic of China, ⁵Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States

We demonstrate that off-resonance VDMP can be used as an exchange rate filter to distinguish and quantify the slow- and fast-exchanging components in Z-spectra by applying an appropriate number of pulses and varying the mixing times. The method can be used to extract predominantly fast-exchanging protons by separating out the slow-MTC pool, and provides information about the chemical exchanging species in tissue that conventional MT/CEST technique cannot access.

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