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Abstract #3770

Separating out Fast and Slow Chemical Exchange Using Off-resonance Variable Delay Multiple Pulse (VDMP)

Lin Chen1,2,3, Xiang Xu2,3, Haifeng Zeng2,3, Kannie W.Y. Chan2,3,4, Nirbhay Yadav2,3, Shuhui Cai1, Kathryn J. Schunke5, Nauder Faraday5, Peter C. M. van Zijl2,3, and Jiadi Xu2,3

1Department of Electronic Science, Xiamen University, Xiamen, People's Republic of China, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 4Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, People's Republic of China, 5Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States

We demonstrate that off-resonance VDMP can be used as an exchange rate filter to distinguish and quantify the slow- and fast-exchanging components in Z-spectra by applying an appropriate number of pulses and varying the mixing times. The method can be used to extract predominantly fast-exchanging protons by separating out the slow-MTC pool, and provides information about the chemical exchanging species in tissue that conventional MT/CEST technique cannot access.

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