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Abstract #3771

Chemical Exchange Rotation Transfer Imaging of CEST signal at 2ppm

Zhongliang Zu1, Elizabeth A Louie1, Eugene Lin1, Xiaoyu Jiang1, Mark D Does1, John C Gore1, and Daniel F Gochberg1

1Vanderbilt University, Nashville, TN, United States

The CEST signal around 2 ppm may have applications in cancer and muscle imaging and is likely related to an important energy molecule, creatine. In this work, we provide a specific metric to better quantify this signal based on modification of our previously developed CERT approach and an inverse analysis. Results show that the CEST signal at 2 ppm is hypointense in tumors which may be due to decreased creatine content.

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