Chemical exchange saturation transfer (CEST) is observed by applying off-resonance saturation pulses at multiple frequencies and measuring the change in water signal. However, if lipid molecules are present, signals from both species contribute to overall voxel signal, confounding spectral measurement. A multiple gradient echo sequence was developed to simultaneously perform chemical shift imaging with CEST to decouple these signals and measure the independent effect of off-resonance saturation transfer to water. 2D spectra were reconstructed, from which individual water-only z-spectra were obtained. In data from a mixed species phantom, amide proton peaks were clearly visible despite the presence of lipid signal.
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