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Abstract #3773

Chemical exchange-sensitive MRI at 9.4 T versus 15.2 T:  Effect on Sensitivity and Background Signals

Julius Juhyun Chung1,2, Wonmin Choi1,3, Tao Jin4, Jung Hee Lee1,2,3,5, and Seong-Gi Kim1,2,3

1Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, 2Samsung Advanced Insitute for Health Sciences and Technology, SKKU, Seoul, Korea, Republic of, 3Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 4Radiology, University of Pittsburgh, 5Radiology, Sungkyunkwan University, Seoul, Korea, Republic of

With chemical-exchange sensitive imaging, increasing field narrows the linewidth of magnetization transfer effects and shifts relative exchange rates (exchange rate vs. chemical shift) toward a slower exchange regime. This study is intended to explore the interplay of contrast mechanisms and sensitivity benefits by comparing phantom and in-vivo data acquired at the fields of 9.4T and 15.2T. The linewidth narrowing effect between the fields is demonstrated in agar phantoms with nicotinamide as well as spectra from the rat cortex. Spectra taken at higher power shows increase of sensitivity by shifting toward a slower exchange regime.

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