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Abstract #3774

Dual-CEST: a novel 3D-CEST sequence exploiting simultaneous transverse and longitudinal CEST signal encoding.

Robert C. Brand1, Nicholas P. Blockley1, Michael A. Chappell2, and Peter Jezzard1

1Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Department of Engineering Science, University of Oxford, Oxford, United Kingdom

We propose a novel 3D method called Dual-CEST, which simultaneously captures the CEST contrast stored in the longitudinal and transverse magnetisation of the bulk water. By including ADC events and a hexagonal spoiling scheme during the CEST preparation phase we collected the usually neglected transverse signal, generated by direct water saturation (a method we call NoXi-CEST). The unaffected longitudinal magnetisation is then acquired using a 3D-GRASE readout resulting in one (Dual-CEST) sequence (3:15 min) that provides XY-spectra, in addition to conventional Z-spectra, and producing additional CEST-contrast and B0-maps without loss of contrast or additional scan time (compared with conventional imaging).

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