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Abstract #3776

Dominant pH-sensitive amide proton transfer effect during acute ischemic stroke - Quantification of multi-pool contribution to commonly used MTRasym analysis in a rat model of acute stroke

Yin Wu1, Iris Yuwen Zhou2, Jing Zhao1, and Phillip Zhe Sun2

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People's Republic of China, 2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, MA, United States

Routinely used magnetization transfer (MT) asymmetry in measurement of pH-sensitive amide proton transfer (APT) effect is susceptible to concomitant contributions, including semisolid MT and nuclear overhauser effect (NOE). In this study, multi-pool contribution from NOE, MT, CEST at 2 ppm and APT during the acute stroke was resolved with a sum of five Lorentzian functions. Results confirmed the changes in MT and NOE offset each other, and reduction of APT was approximately two-fold of the CEST effect decrease at 2 ppm, dominating the commonly observed pH-sensitive MTRasym change during acute stroke.

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