Abstract #3776

Dominant pH-sensitive amide proton transfer effect during acute ischemic stroke - Quantification of multi-pool contribution to commonly used MTRasym analysis in a rat model of acute stroke

Yin Wu¹, Iris Yuwen Zhou², Jing Zhao¹, and Phillip Zhe Sun²

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People's Republic of China, ²Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, MA, United States

Routinely used magnetization transfer (MT) asymmetry in measurement of pH-sensitive amide proton transfer (APT) effect is susceptible to concomitant contributions, including semisolid MT and nuclear overhauser effect (NOE). In this study, multi-pool contribution from NOE, MT, CEST at 2 ppm and APT during the acute stroke was resolved with a sum of five Lorentzian functions. Results confirmed the changes in MT and NOE offset each other, and reduction of APT was approximately two-fold of the CEST effect decrease at 2 ppm, dominating the commonly observed pH-sensitive MTR_asymchange during acute stroke.

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