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Abstract #3777

Towards Fast Quantitative CEST: A New Model for Quantifying the CEST Effect in the Presence of MT

Alex K Smith1,2,3, Richard D. Dortch2,3,4, and Seth A Smith2,3,4,5

1FMRIB, University of Oxford, Oxford, United Kingdom, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 4Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 5Department of Ophthalmology, Vanderbilt University, Nashville, TN, United States

Basic models to characterize the CEST effect in vivo suffer from competing magnetization transfer (MT) effects. Here, we use qMT to model the CEST effect and derive CEST indices that are independent of MT. Additionally, simultaneously assessing the MT and CEST effects provides more robust estimates of other elements of the MT effect. Simulations and initial in vivo findings suggest that combining MT and CEST fitting provides a more accurate fit of CEST z-spectra than a traditional single pool Lorentzian fit, and thus provides estimates of the CEST effect that are not dependent on the MT effect.

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