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Abstract #3779

Model-Based Analysis of Partial Z-spectra for Rapid Quantification of Amide Proton Transfer MRI

Paula L. Croal1, Kevin Ray2, Yunus Msayib1, James Larkin2, Brad Sutherland3,4, George Harston3, Andy Baldwin5, Alastair Buchan3, Peter Jezzard6, James Kennedy3, Nicola Sibson2, and Michael Chappell1

1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 2Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom, 3Acute Vascular Imaging Centre & Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 4School of Medicine, Faculty of Health, University of Tasmania, Hobart, Australia, 5Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom, 6Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Model-based analysis of APT MRI has been shown to quantitatively outperform conventional approaches such as asymmetry analysis. However clinical application is hindered by slow acquisition of whole z-spectra, and processing times. Here, we demonstrate that by using only a subset of frequency offsets, acquisition and processing time can be reduced by ~70% and ~90%, respectively. Using an MCAO model of ischemic stroke, we demonstrate that our Reduced Frequency Offset approach is able to detect significant differences in APTR* between healthy and ischemic tissue.

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