Abstract #3779

Model-Based Analysis of Partial Z-spectra for Rapid Quantification of Amide Proton Transfer MRI

Paula L. Croal¹, Kevin Ray², Yunus Msayib¹, James Larkin², Brad Sutherland^3,4, George Harston³, Andy Baldwin⁵, Alastair Buchan³, Peter Jezzard⁶, James Kennedy³, Nicola Sibson², and Michael Chappell¹

¹Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ²Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom, ³Acute Vascular Imaging Centre & Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁴School of Medicine, Faculty of Health, University of Tasmania, Hobart, Australia, ⁵Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom, ⁶Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Model-based analysis of APT MRI has been shown to quantitatively outperform conventional approaches such as asymmetry analysis. However clinical application is hindered by slow acquisition of whole z-spectra, and processing times. Here, we demonstrate that by using only a subset of frequency offsets, acquisition and processing time can be reduced by ~70% and ~90%, respectively. Using an MCAO model of ischemic stroke, we demonstrate that our Reduced Frequency Offset approach is able to detect significant differences in APTR* between healthy and ischemic tissue.

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