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Abstract #3780

Peak RF Optimization for Baseline Enhancement (PROBE) for CEST/NOE with in-vitro application at 7T

Tobias Lenich1, André Pampel1, Toralf Mildner1, Riccardo Metere1, and Harald E. Möller1

1Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

In CEST/NOE experiments, induced saturation intended for certain metabolites also saturates other moieties, leading to mingled backgrounds in Z-spectra. Precise quantification of endogenous metabolites is impeded by slow acquisition times and confounding background contributions. We present an optimization framework targeting a flattened baseline in Z-spectra, with direct water saturation and non-specific macromolecular contributions fully compensated. Saturation pulse amplitudes as a function of frequency offset were derived using optimal-control-based calculation. Feasibility of this approach is demonstrated in vitro for NOE/CEST in the presence of tissue-like background and accelerated acquisition by distinct offset selection. Experimental results show good agreement with concentration levels.

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