Abstract #3789

In Vivo Deuterium Labeling and Detection Of Organs Containing Rapidly Dividing Cells

Martin J Lizak¹, Natella Maglakelidze², Brittany Oliver², Don E Farthing², Hellmut Merkle³, Ronald E Gress⁴, and Nataliya P Buxbaum⁵

¹Mouse Imaging Facility, NINDS, National Institutes of Health, Bethesda, MD, United States, ²Experimental Transplantation and Immunology Branch, NCI, National Institutes of Health, Bethesda, MD, ³Laboratory for Functional and Molecular Imaging, NINDS, National Institutes of Health, Bethesda, MD, United States, ⁴Experimental Transplantation and Immunology Branch, NCI, National Institutes of Health, Betesda, MD, United States, ⁵Experimental Transplantation and Immunology Branch, NCI, National Institutes of Health, Bethesda, MD, United States

In vivo deuterium labeling via ingestion of deuterated water was combined with magnetic resonance imaging to demonstrate a method for studying diseases with groups of rapidly dividing cells. This method was applied to a mouse model of chronic graft versus host disease to demonstrate feasibility.

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