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Abstract #3790

Fast Field-Cycling NMR of human glioma resections: characterization of heterogeneity

Lionel Marc Broche1, Yang Huang2, Sandra Pierre2, Francois Berger2, David J Lurie1, Pascal Henry Fries3, and Hana Lahrech2

1University of Aberdeen, Aberdeen, United Kingdom, 2U1205 BrainTech Lab, INSERM, Grenoble, France, 3INAC-SCIB, CEA, Grenoble, France

FFC-NMR is a unique tool for the measurements of molecular dynamics in the range of nano- to microseconds. With the development of FFC-MRI scanner, it is now possible to investigate new contrasts using field-dependant variations of T1 to obtain quantitative markers in diseases. In this work we investigate what information FFC-NMR can provide in the context of glioma, using frozen human brain resection from glioma and epileptic surgery. We found that the quadrupolar peaks and T1 dispersions values may be useful biomarkers.

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