Abstract #3790

Fast Field-Cycling NMR of human glioma resections: characterization of heterogeneity

Lionel Marc Broche¹, Yang Huang², Sandra Pierre², Francois Berger², David J Lurie¹, Pascal Henry Fries³, and Hana Lahrech²

¹University of Aberdeen, Aberdeen, United Kingdom, ²U1205 BrainTech Lab, INSERM, Grenoble, France, ³INAC-SCIB, CEA, Grenoble, France

FFC-NMR is a unique tool for the measurements of molecular dynamics in the range of nano- to microseconds. With the development of FFC-MRI scanner, it is now possible to investigate new contrasts using field-dependant variations of T₁ to obtain quantitative markers in diseases. In this work we investigate what information FFC-NMR can provide in the context of glioma, using frozen human brain resection from glioma and epileptic surgery. We found that the quadrupolar peaks and T₁ dispersions values may be useful biomarkers.

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