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Abstract #3883

Validation of an Image Derived Input Function Method for PET/MR Brain Scans

Mohammad Mehdi Khalighi1, Mathias Engström2, Mark Lubberink3, and Greg Zaharchuk4

1Applied Science Lab, GE Healthcare, Menlo Park, CA, United States, 2Applied Science Lab, GE Healthcare, Uppsala, Sweden, 3Nuclear Medicine & PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, 4Radiology Department, Stanford University, Palo Alto, CA, United States

Accurate measurement of the arterial input function (AIF) is essential in quantitative analysis of cerebral blood flow (CBF) using 15O-water PET imaging. The time-of-flight enabled SIGNA PET/MR scanner (GE Healthcare, Waukesha, WI, USA) provides high quality PET images, which can be used for non-invasive Image Derived Input Function (IDIF) estimation. AIF was measured using a proposed IDIF method on 4 patients and the results were compared with the gold standard, arterial blood sampling. The comparison shows excellent correspondence between IDIF and blood sampling, thus validating the IDIF method.

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