Abstract #3884

Whole-body morphological and functional atlas using an integrated PET-MRI system and fat-water registration

Simon Ekström¹, Therese Sjöholm¹, Filip Malmberg^1,2, Lars Lind³, Håkan Ahlström^1,4, Joel Kullberg^1,4, and Robin Strand^1,2

¹Division of Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, ²Centre for Image Analysis, Uppsala University, Uppsala, Sweden, ³Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁴Antaros Medical, Sweden

Today, when whole-body PET-MRI datasets are analyzed, the data is typically reduced to a few a priori specified measurements. New tools are developed in an attempt to utilize the full potential of large whole-body datasets. The purpose of this work was to build a preliminary whole-body atlas, containing both morphological (fat and water MR) and functional (FDG-PET) information on normality. An atlas was built out of 30 subjects using an integrated PET-MRI system together with an efficient registration method for fat-water MR images. The atlas was used in a proof-of-concept anomaly detection in FDG-PET using a pointwise t-test, which successfully detected anomalies in our test subject.

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