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Abstract #3884

Whole-body morphological and functional atlas using an integrated PET-MRI system and fat-water registration

Simon Ekström1, Therese Sjöholm1, Filip Malmberg1,2, Lars Lind3, Håkan Ahlström1,4, Joel Kullberg1,4, and Robin Strand1,2

1Division of Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, 2Centre for Image Analysis, Uppsala University, Uppsala, Sweden, 3Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 4Antaros Medical, Sweden

Today, when whole-body PET-MRI datasets are analyzed, the data is typically reduced to a few a priori specified measurements. New tools are developed in an attempt to utilize the full potential of large whole-body datasets. The purpose of this work was to build a preliminary whole-body atlas, containing both morphological (fat and water MR) and functional (FDG-PET) information on normality. An atlas was built out of 30 subjects using an integrated PET-MRI system together with an efficient registration method for fat-water MR images. The atlas was used in a proof-of-concept anomaly detection in FDG-PET using a pointwise t-test, which successfully detected anomalies in our test subject.

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