Current techniques for skull attenuation correction in PET-MRI provide indirect estimates of cortical bone density, leading to inaccurate estimates of brain activity. Here we propose an alternate method based on the detection of hydroxyapatite crystals by 31P-MRI, providing individual and quantitative assessment of bone density. 31P-MRI was performed in rodent to estimate the µ-map of the skull. FDG-PET data were acquired in the same animal and reconstructed with 31P-based attenuation correction, demonstrating proper distribution of 18F activity throughout the brain.
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