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Abstract #3893

Using 31P-MRI of hydroxyapatite for bone attenuation correction in PET-MRI: proof of concept in the rodent brain

Vincent Lebon1, Sébastien Jan2, Yoann Fontyn2, Brice Tiret3, Géraldine Pottier2, Emilie Jaumain2, and Julien Valette3

1DRF/I2BM/SHFJ, CEA, Orsay, France, 2DRF/I2BM/SHFJ/IMIV, CEA-Université Paris Saclay, Orsay, France, 3DRF/I2BM/MIRCen/UMR9199, CEA-CNRS-Université Paris Saclay, Fontenay-aux-Roses, France

Current techniques for skull attenuation correction in PET-MRI provide indirect estimates of cortical bone density, leading to inaccurate estimates of brain activity. Here we propose an alternate method based on the detection of hydroxyapatite crystals by 31P-MRI, providing individual and quantitative assessment of bone density. 31P-MRI was performed in rodent to estimate the µ-map of the skull. FDG-PET data were acquired in the same animal and reconstructed with 31P-based attenuation correction, demonstrating proper distribution of 18F activity throughout the brain.

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