Abstract #3894

Water content, diffusion measures (DTI/DKI) and FET-PET in brain tumours: investigating similarities and differences

Ana-Maria Oros-Peusquens*¹, Ricardo Loucao*^1,2, Hugo Ferreira², Karl-Josef Langen¹, and Nadim Jon Shah¹

¹INM-4, Research Centre Jülich, Jülich, Germany, ²Instituto de Biofísica e Engenharia Biomédica, Sciences Faculty, University of Lisbon, Lisbon, Portugal

Water content, diffusion measures and FET-PET measured simultaneously on a hybrid 3T scanner in 40 brain tumour patients were investigated. Despite reasonable expectations of finding some microscopic-structure-driven correlations between these parameters, compared here for the first time, low correlations were found in healthy tissue. Interestingly, the correlation between water content and diffusion indices -while still rather low - increased in tumour tissue. Importantly, this implies that each parameter reflects different aspects and thus their combination should be more powerful for oncology than using single parameters

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