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Abstract #4040

Tissue Relaxometry Defined (TRD) pseudo-CT imaging based on a single multi-gradient-echo MRI scan

Jie Wen1, Bin Cai2, Michael Gach2, Olga Green2, Christina Tsien2, Jiayi Huang2, Sasa Mutic2, and Dmitriy Yablonskiy1

1Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2Radiation Oncology, Washington University in St. Louis, St. Louis, MO, United States

Generating MRI-based pseudo-CT images, providing electron density information for dose calculation, is the first step towards MRI-based radiation therapy treatment planning. Existing methods either require prior knowledge of a CT-MR atlas or require acquisition of multiple scans. In this study, we demonstrated the feasibility of producing pseudo-CT images by using a single multi-gradient-echo sequence. This method takes advantage of tissue-specific relaxation properties of MRI signal to provided segmentation of bone, air and other anatomical structures. Since all images are generated from a single scan and are naturally co-registered, this method is fast and avoids registration errors.

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