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Abstract #4039

Human In-vivo MR Current Density Imaging (MRCDI) Based on Optimized Multi-echo Spin Echo (MESE)

Cihan Göksu1,2, Lars Grüner Hanson1,2, Philipp Ehses3,4, Klaus Scheffler3,4, and Axel Thielscher1,2,3

1Center for Magnetic Resonance, DTU Elektro, Technical University of Denmark, Kgs. Lyngby, Denmark, 2Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark, 3High-Field Magnetic Resonance Center, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, 4Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany

MRCDI aims at imaging an externally injected current flow in the human body, and might be useful for many biomedical applications. However, the method requires very sensitive measurement of the current-induced magnetic field component ∆Bz,c parallel to main field. We systematically optimized MESE to determine its most efficient parameters. In one of the first human in-vivo applications of MRCDI, the optimized sequence was successfully used to image the ∆Bz,c distribution in the brain caused by a two-electrode montage, as confirmed by finite-element calculations of ∆Bz,c. Further improvements will be performed to increase its robustness to field drifts.

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