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Abstract #4043

Impact of Magnetic Susceptibility Anisotropy at 3 T and 7 T on T2*-based Myelin Water Fraction Imaging

Eva Alonso Ortiz1, Ives R. Levesque1,2, and G. Bruce Pike3

1McGill University, Montreal, QC, Canada, 2Research Institute, McGill University Health Centre, Montreal, QC, Canada, 3University of Calgary, Calgary, AB, Canada

In this work we estimated the impact of myelin’s magnetic susceptibility anisotropy on the Myelin Water Fraction (MWF) at 3T and 7T. We simulated realistic multicomponent T2* decay and then computed the MWF using three different fitting models. Our findings indicate that the effect of myelin’s magnetic susceptibility anisotropy does not need to be considered when computing the MWF at 3T. However, failure to do so at 7T can lead to a significant bias in the MWF.

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