To track evolution of multiple sclerosis (MS) lesions, 9 patients underwent gradient-echo-T2* and quantitative susceptibility mapping on 7T MR system at baseline and at follow-up period (mean duration=2.4years). Majority of lesions were non-iron laden at baseline and most of them remained unchanged in size, morphology and susceptibility patterns. Some of these lesions accumulated iron deposition on follow-up. A minority of iron-laden lesions underwent redistribution of iron content. Small increase in lesion count was observed at follow-up. Interestingly, majority of these lesions were iron-enriched. This study may provide insights into pathophysiological features of MS lesions during the course of disease evolution.