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Abstract #4046

Longitudinal Study of MS lesions using Multi-contrast Ultra-high Field (7Tesla) MRI

SANJEEV CHAWLA1, Ilya Kister2, Tim Sinnecker3, Jens Thomas Wuerfel4, Friedemann Paul5, and Yulin Ge6

1Radiology, UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA, United States, 2Neurology, Multiple Sclerosis Care Center, NYU School of Medicine, New York, NY, United States, 3Neurology, Universitätsspital, Basel, Switzerland, 4Medical Image Analysis Center, Basel, Switzerland, 5NeuroCure Clinical Research Center, Charité-Universitätsmedizin, Berlin, Germany, 6Radiology, NYU School of Medicine, New York, NY, United States

To track evolution of multiple sclerosis (MS) lesions, 9 patients underwent gradient-echo-T2* and quantitative susceptibility mapping on 7T MR system at baseline and at follow-up period (mean duration=2.4years). Majority of lesions were non-iron laden at baseline and most of them remained unchanged in size, morphology and susceptibility patterns. Some of these lesions accumulated iron deposition on follow-up. A minority of iron-laden lesions underwent redistribution of iron content. Small increase in lesion count was observed at follow-up. Interestingly, majority of these lesions were iron-enriched. This study may provide insights into pathophysiological features of MS lesions during the course of disease evolution.

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