Abstract #4061

THE EVOLUTION OF CORTICAL AND SUB-CORTICAL LESION SIZE AND NUMBER CORRELATES WITH CHANGES IN COGNITION IN EARLY-STAGE RELAPSING-REMITTING MULTIPLE SCLEROSIS PATIENTS

Alexandra Şorega¹, Mário João Fartaria ^2,3,4, Guillaume Bonnier⁵, Tobias Kober^2,3,4, Renaud Du Du Pasquier⁶, Myriam Schluep⁶, Gunnar Krueger⁷, Meritxell Bach Cuadra^3,4,8, and Cristina Granziera^5,6

¹Department of Radiology, Valais Hospital, Sion, Switzerland, ²Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ³Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁴Signal Processing Laboratory (LTS 5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁵Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ⁶Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁷Siemens Medical Solutions USA, Boston, MA, United States, ⁸Medical Image Analysis Laboratory (MIAL), Centre d'Imagerie BioMédicale (CIBM), Lausanne, Switzerland

Lesion load and activity in multiple sclerosis (MS) patients, as identified by conventional magnetic resonance imaging (MRI), correlate only moderately with patients clinical status and evolution. Cortical lesion number and volume measured with advanced MRI may provide better correlates to cognitive dysfunction and disability. In this work, we studied the clinical impact of advanced MRI metrics of cortical and subcortical lesion evolution in a cohort of early relapsing-remitting MS patients. The number and volume of lesions that “shrunk”, disappeared or remained stable over time were strong determinants of changes in cognition in our patients cohort.

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