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Abstract #4062

Longitudinal outer and inner cortical MTR abnormalities in different MS clinical phenotypes

Rebecca Sara Samson1, Manuel J Cardoso2,3, Nils Muhlert1,4, Varun Sethi1,5, Özgür Yaldizli1,6, Maria A Ron1, Ferran Prados 1,2, Sebastian Ourselin2,3, David H Miller1,7, Claudia A M Gandini Wheeler-Kingshott1,8,9, and Declan T Chard1,7

1UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, 2Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 3Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, University College London, London, United Kingdom, 4Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, 5Department of Neurology, Nottingham University Hospitals, Nottingham, United Kingdom, 6Department of Neurology, University Hospital Basel, Basel, Switzerland, 7National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre, United Kingdom, 8Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 9Brain MRI 3T Center, C. Mondino National Neurological Institute, Pavia, Italy

Outer cortical magnetisation transfer ratio (cMTR) is potentially a sensitive measure of pathology linked to clinical disease progression in multiple sclerosis (MS). Here we aimed to investigate longitudinal outer and inner cMTR changes in healthy controls (HC) and people with MS of different clinical subtypes. Follow-up (FU) outer cMTR showed larger reductions in secondary progressive (SP)MS than other subtypes, and inner cMTR was also reduced more than in HC and relapsing-remitting (RR)MS, although cMTR was reduced in all MS patients at FU. This supports histopathological findings and suggests that cMTR measurement may be relevant to clinical disease progression in MS.

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