Abstract #4062

Longitudinal outer and inner cortical MTR abnormalities in different MS clinical phenotypes

Rebecca Sara Samson¹, Manuel J Cardoso^2,3, Nils Muhlert^1,4, Varun Sethi^1,5, Özgür Yaldizli^1,6, Maria A Ron¹, Ferran Prados ^1,2, Sebastian Ourselin^2,3, David H Miller^1,7, Claudia A M Gandini Wheeler-Kingshott^1,8,9, and Declan T Chard^1,7

¹UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, ²Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ³Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, University College London, London, United Kingdom, ⁴Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, ⁵Department of Neurology, Nottingham University Hospitals, Nottingham, United Kingdom, ⁶Department of Neurology, University Hospital Basel, Basel, Switzerland, ⁷National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre, United Kingdom, ⁸Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁹Brain MRI 3T Center, C. Mondino National Neurological Institute, Pavia, Italy

Outer cortical magnetisation transfer ratio (cMTR) is potentially a sensitive measure of pathology linked to clinical disease progression in multiple sclerosis (MS). Here we aimed to investigate longitudinal outer and inner cMTR changes in healthy controls (HC) and people with MS of different clinical subtypes. Follow-up (FU) outer cMTR showed larger reductions in secondary progressive (SP)MS than other subtypes, and inner cMTR was also reduced more than in HC and relapsing-remitting (RR)MS, although cMTR was reduced in all MS patients at FU. This supports histopathological findings and suggests that cMTR measurement may be relevant to clinical disease progression in MS.

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