Abstract #4063

Monitoring Disease Progression in Experimental Autoimmune Encephalitis using VDMP-CEST MRI

Aline Thomas¹, Jiadi Xu², Peter Van Zijl², and Jeff Bulte³

¹Johns Hopkins School of Medicine, Baltimore, MD, United States, ²Kennedy Krieger, ³Johns Hopkins School of Medicine

VDMP-CEST MRI can spatiotemporally monitor disease progression in a mouse model of multiple sclerosis. Lower VDMP-CEST signals corresponded to a decreased lipid and metabolite content in the peri-ventricular region of the brain, characteristic of the disease, with magnetic resonance spectroscopy used as validation.

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