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Abstract #4066

Using multi-inversion time ASL to explore gray matter perfusion in patients with multiple sclerosis: repeatability and relationship to disease characteristics

Ilona Lipp1, Catherine Foster1, Rachael Stickland1, Alison Davidson1, Richard G Wise1, and Valentina Tomassini1,2

1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2IRCCS Fondazione Santa Lucia, Rome, Italy

The first aim of this study was to investigate retest-reliability of gray matter perfusion estimates in patients with multiple sclerosis. Using multi-inversion time pulsed ASL, we demonstrate good repeatability of global and local perfusion estimates over a four-week interval. The perfusion estimates were consistently lower in the patients than in a group of healthy controls. The second aim was to relate GM perfusion to disease characteristics. We could not find an effect of disease duration or stage (relapsing-remitting vs progressive) on perfusion, but we did observe a weak correlation with cognition, supporting previous studies.

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