Knowledge of reproducibility of graph-theoretic brain network metrics in disease populations is critically important for applications in clinical studies but non-existent in published literature. We compared reproducibility of graph metrics over time in a cohort of MS patients to reported values in published studies of reproducibility in healthy volunteers. We found that reproducibility was good in MS patients but slightly lower than in healthy people. Reproducibility of graph-theoretic brain network metrics in MS patients is not greatly dissimilar to that in healthy populations, which supports their use in clinical studies.
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