Purpose: To create an anatomically-interpretable framework for localized analysis of brain iron accumulation/demyelination, and apply this framework to Multiple Sclerosis (MS) Deep Gray Matter (DGM).
Materials and Methods: Quantitative Susceptibility and R2* maps were computed for 110 MS and 75 control subjects.
Results: Significant iron accumulation and insignificant demyelination were detected in MS DGM. Common MS pathological volumes and their pathological effect size progressively increased with advanced phenotypes. The developed framework offered improved statistical power and iron specificity compared to whole structure and singular analysis.
Conclusion: Using a novel localized analysis pipeline, we demonstrated the progressive iron accumulation in MS DGM.