Meeting Banner
Abstract #4068

Progressive Iron Accumulation in Multiple Sclerosis Phenotypes Revealed by Sparse Classification of Deep Gray Matter

Ahmed M. Elkady1, Dana Cobzas1, Hongfu Sun1, Gregg Blevins2, and Alan H. Wilman1

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Division of Neurology, University of Alberta, Edmonton, AB, Canada

Purpose: To create an anatomically-interpretable framework for localized analysis of brain iron accumulation/demyelination, and apply this framework to Multiple Sclerosis (MS) Deep Gray Matter (DGM).

Materials and Methods: Quantitative Susceptibility and R2* maps were computed for 110 MS and 75 control subjects.

Results: Significant iron accumulation and insignificant demyelination were detected in MS DGM. Common MS pathological volumes and their pathological effect size progressively increased with advanced phenotypes. The developed framework offered improved statistical power and iron specificity compared to whole structure and singular analysis.

Conclusion: Using a novel localized analysis pipeline, we demonstrated the progressive iron accumulation in MS DGM.

This abstract and the presentation materials are available to members only; a login is required.

Join Here