Fifty Multiple Sclerosis subjects were evaluated by optical coherence tomography and MRI, including multi-shell and putative myelin content imaging focused on primary visual area, thalamus and cerebellum. Predictive models of visual function performance, measured by visual evoked potentials and low contrast visual acuity were tested using a partial least square regression analysis. Combination of MRI and OCT metrics appears to strongly describe the visual function. Myelin content imaging, in particular, has a strong predictive value once there is history of optic neuritis. These preliminary results may improve the understanding of the pathological mechanisms underlying clinical dysfunction in multiple sclerosis.