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Abstract #4076

Effects of SHH Signaling Pathway in Post-Stroke Recovery Assessed by MRI

Yifan Zhang1, Yongming Jin2, Agnes Yu Luo2, and Xin Yu1

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Neurological Surgery, Case Western Reserve University, Cleveland, OH, United States

The current study investigated the effect of sonic hedgehog agonist (SAG) treatment in post-stroke recovery. SAG- and vehicle-treated mice were evaluated with MRI at day 2 and day 30 after middle cerebral artery occlusion (MCAO) surgery. Our results show that SAG treatment showed significantly increased cerebral perfusion in the ischemic penumbra at day 30, suggesting enhanced angiogenesis. In addition, SAG-treated mice also exhibited decreased T2, suggesting reduced neuronal damage. These results suggest that the sonic hedgehog signaling pathway can be a potential therapeutic target for stroke treatment.

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