Abstract #4075

Diffusion MRI Quantifies Hippocampal CA1 Dendritic Loss and Inflammation in TMEV-Induced Epilepsy

Jie Zhan¹, Tsen-Hsuan Lin², Jane E. Libbey³, Peng Sun², Ze-Zhong Ye⁴, Chunyu Song⁵, Michael Wallendorf⁶, Honghan Gong¹, Robert S. Fujinami³, and Sheng-Kwei Song^2,5,7

¹Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China, ²Radiology, Washington University in St. Louis, St. Louis, MO, United States, ³Pathology, University of Utah, Salt Lake City, UT, United States, ⁴Chemsitry, Washington University in St. Louis, St. Louis, MO, United States, ⁵Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States, ⁶Biostatistics, Washington University in St. Louis, ⁷Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, United States

Hippocampal neuronal damage and inflammation are the hallmark pathologies of epilepsy. We demonstrate the capability of diffusion based spectrum imaging (DBSI) to quantify hippocampal CA1 neuronal dendritic injury/loss and inflammation in TMEV-induced epilepsy mice, followed by immunohistochemistry (IHC) validation. Results demonstrate that both DTI and DBSI metrics changed in CA1 region of TMEV-induced seizure mouse. DBSI-derived fiber fraction correlated with MAP2-positive area fraction, and DBSI-derived restricted isotropic diffusion fraction correlated with DAPI-positive nucleus density.

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