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Abstract #4075

Diffusion MRI Quantifies Hippocampal CA1 Dendritic Loss and Inflammation in TMEV-Induced Epilepsy

Jie Zhan1, Tsen-Hsuan Lin2, Jane E. Libbey3, Peng Sun2, Ze-Zhong Ye4, Chunyu Song5, Michael Wallendorf6, Honghan Gong1, Robert S. Fujinami3, and Sheng-Kwei Song2,5,7

1Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China, 2Radiology, Washington University in St. Louis, St. Louis, MO, United States, 3Pathology, University of Utah, Salt Lake City, UT, United States, 4Chemsitry, Washington University in St. Louis, St. Louis, MO, United States, 5Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States, 6Biostatistics, Washington University in St. Louis, 7Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO, United States

Hippocampal neuronal damage and inflammation are the hallmark pathologies of epilepsy. We demonstrate the capability of diffusion based spectrum imaging (DBSI) to quantify hippocampal CA1 neuronal dendritic injury/loss and inflammation in TMEV-induced epilepsy mice, followed by immunohistochemistry (IHC) validation. Results demonstrate that both DTI and DBSI metrics changed in CA1 region of TMEV-induced seizure mouse. DBSI-derived fiber fraction correlated with MAP2-positive area fraction, and DBSI-derived restricted isotropic diffusion fraction correlated with DAPI-positive nucleus density.

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